The Command key shortcuts can be used with your iPad during a Remote Desktop connections. The "Opt ⌥ <-> cmd ⌘" button remaps the left Option key ⌥ to function as the Command key ⌘, preventing iOS from capturing combos like cmd-tab and cmd-space when you use opt-tab and opt-space instead. See images below:

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     Shortcut keys are OFF

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      Shortcut keys are ON

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If you encounter any issues or have any questions, feel free to reach out to our support at team@duetdisplay.com. We'll be happy to help!